2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (512):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-171862
    Nef ligand-2 3066896-28-1
    Nef ligand-2 is a binder of Nef. Nef ligand-2 is Ligands for E3 Ligase. Nef ligand-2 is the Nef Binder portion of FC-14369 (HY-171860).
    Nef ligand-2
  • HY-178313
    EGFR ligand-18
    EGFR ligand-18 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as PROTAC EGFR degrader 16 (HY-178242). PROTAC EGFR degrader 16 is a potent EGFR PROTAC degrader with anti-tumor activity.
    EGFR ligand-18
  • HY-169379
    CSI118 TFA 3063898-01-8
    CSI118 TFA (Compound 1) is a Ligand for Target Protein for PROTAC. CSI118 TFA can be used to synthesize CSI86 (HY-169378).
    CSI118 TFA
  • HY-143270
    PROTAC BRD9-binding moiety 5 893633-37-9
    PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC50 value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells.
    PROTAC BRD9-binding moiety 5
  • HY-181733
    KRAS G12D ligand-3
    KRAS G12D ligand-3 is a KRAS G12D PROTAC ligand. KRAS G12D ligand-3 can be conjugated with E3 ligase Ligand (HY-170348) and linke (HY-W895436) to synthesize KRAS G12D PROTAC degrader MS243 (HY-181728). MS243 can be used for cancer research.
    KRAS G12D ligand-3
  • HY-19991A
    (Rac)-BMS-1 1675201-97-4
    (Rac)-BMS-1 is a racemate of BMS-1 (HY-19991A). (Rac)-BMS-1 can be used as a target protein ligand to synthesize D5B PROTAC (HY-169392).
    (Rac)-BMS-1
  • HY-174225
    sEH-H ligand 1
    sEH-H ligand 1 is a PROTAC target protein ligand that can be used to synthesize PROTAC sEH degrader-2 (HY-174443).
    sEH-H ligand 1
  • HY-111845
    Estrone-N-O-C1-amido 138219-84-8
    Estrone-N-O-C1-amido (ERα ligand 1) is an Estrone-based estrogen ligand, which targets estrogen receptor α (ERα). Estrone-N-O-C1-amido (ERα ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.
    Estrone-N-O-C1-amido
  • HY-176382
    BCL6 ligand-4 2257479-50-6
    BCL6 ligand-4 is an BCL6 ligand that can be used in the synthesis of PROTACs, such as BCL6 PROTAC 1 (HY-122829).
    BCL6 ligand-4
  • HY-174868
    iP300w 3055107-60-0
    iP300w (Compound 9) is a Histone acetyltransferase p300 (KAT3B) inhibitor. iP300w can be used for synthesis of PROTAC BT-O2C (HY-174866).
    iP300w
  • HY-168017
    NSC682769 205048-79-9
    NSC682769 is a PROTAC YAP-targeting ligand (Ligands for Target Protein for PROTACs). NSC682769 can be used for synthesis PROTAC YAP degrader-1 (HY-168016).
    NSC682769
  • HY-168897
    LC3B ligand 1 902959-52-8
    LC3B ligand 1 is a ligand for the target protein of PROTAC and can be used for the synthesis of PROTAC CDK9 autophagic degrader 1 (HY-168896).
    LC3B ligand 1
  • HY-176951
    Chaperone complex ligand 1 3048497-50-0
    Chaperone complex ligand 1 is a chaperone ligand for HSP90. Chaperone complex ligand 1 can be connected to the MET ligand (HY-50878) by a linker to synthesis of MET degrader OZD-MET 01 (HY-177893).
    Chaperone complex ligand 1
  • HY-180152
    BRD4 ligand 14
    BRD4 ligand 14 (Compound Y47) is a BRD4 inhibitor. BRD4 ligand 14 exhibits mild anticancer properties against acute myeloid leukemia by inhibiting BRD4. BRD4 ligand 14 can also be used as a ligand for target protein for PROTAC in the development and design of PROTAC BRD4 degraders, such as PROTAC BRD4 Degrader-42 (HY-180150).
    BRD4 ligand 14
  • HY-170452
    MDM2 ligand 4
    MDM2 ligand 4 is the ligand for MDM2 that can be used for synthesis of PROTAC degrader KT-253 (HY-170451).
    MDM2 ligand 4
  • HY-W749028
    ERα ligand 4 97818-93-4
    ERα ligand 4 is a ligand of ERα and can be used for the synthesis of PROTACs, such as NEP168 (HY-180959).
    ERα ligand 4
  • HY-168702
    FLT3 ligand-2 950769-51-4 98.05%
    FLT3 ligand-2 is a Ligand for Target Protein for PROTAC. FLT3 ligand-2 can be used to synthesize PROTAC FLT-3 degrader 1 (HY-114323).
    FLT3 ligand-2
  • HY-171774
    PBRM1/SMARCA2,4-ligand-1 1997321-76-2
    PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to PBRM1, SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1 is a potent SMARCA4 bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118 (HY-163410).
    PBRM1/SMARCA2,4-ligand-1
  • HY-168202
    CCS1477a
    CCS1477a is the active form of the target protein ligand of PROTAC degrader MJP6412 (HY-168201).
    CCS1477a
  • HY-179294
    POI ligand-2 3119292-09-7
    POI ligand-2 is a ligand for GPX4 protein. POI ligand-2 can be used to synthesize PROTAC, such as PROTAC GPX4 degrader-5 (HY-178925).
    POI ligand-2